联系方式
周波教授，1993年毕业于赣南师范学院化学系，1997年和2000年在兰州大学化学化工学院先后获理学硕士和博士学位（有机化学）。2000年-2004年在兰州大学生命科学学院和功能有机分子化学国家重点实验室从事博士后研究。2004年至今在兰州大学功能有机分子化学国家重点实验室工作（2004年12月任有机化学教授）。现为中国生物物理学会自由基生物学与自由基医学分会常务理事、中国环境诱变剂学会活性氧生物学效应专业委员会常务委员。2006年入选教育部“新世纪优秀人才支持计划”。已在国际学术刊物上如J. Am. Chem. Soc., Chem. Eur. J., Free Radic. Biol. Med., Antioxid. Redox Signaling, J. Org. Chem., Mol. Nutr. Food Res., Food Chem., J. Agric. Food Chem.等发表论文90余篇。主要研究领域是自由基化学和自由基生物学、化学生物学、生物有机和药物化学。目前研究兴趣和方向为：基于癌细胞的氧化还原特征设计促氧化抗癌分子。
1、项目：铜介导的促氧化抗癌分子设计及其机制研究（国家自然科学基金面上项目，21672091）；荜茇酰胺等天然产物导向的亲电分子设计、合成及其诱导癌细胞凋亡的活性和机制研究（国家自然科学基金面上项目，21372109）
近5年代表性论文(Representative Publications)：
1. A hydrogen peroxide-activated Cu(II) pro-ionophore strategy for modifying naphthazarin as a promising anticancer agent with high selectivity for generating ROS in HepG2 cells over in L02 cells, Free Radic. Biol. Med. 2020, https://doi.org/10.1016/j.freeradbiomed.2019.12.001.
2. Identification of catechol-type ddiphenylbutadiene as a tyrosinase-activated pro-oxidative chemosensitizer against melanoma A375 Cells via glutathione S-transferase inhibition, J. Agric. Food Chem. 2019, 67:9060-9069.
3. Developing glutathione-activated catechol-type diphenylpolyenes as small molecule-based and mitochondria-targeted prooxidative anticancer theranostic prodrugs, Free Radic. Biol. Med. 2019, 134:406-418.
4. A promising redox cycle-based strategy for designing a catechol-type diphenylbutadiene as a potent prooxidative anti-melanoma agent. Free Radic. Biol. Med. 2019, 130:489-498.
5. Designing dichlorobinaphthoquinone as a prooxidative anticancer agent based on hydrogen peroxide-responsive in situ production of hydroxyl radicals. Eur. J. Med. Chem. 2018, 159:317-323.
6. Designing salicylaldehyde isonicotinoyl hydrazones as Cu(II) ionophores with tunable chelation and release of copper for hitting redox Achilles heel of cancer cells. Free Radic. Biol. Med. 2018, 129:215-216.
7. Targeting redox vulnerability of cancer cells by prooxidative intervention of a glutathione-activated Cu(II) pro-ionophore: Hitting three birds with one stone. Free Radic. Biol. Med. 2018, 124:342-352.
8. A catechol-type resveratrol analog manifests antiangiogenic action by constructing an efficient catalytic redox cycle with intracellular copper ions and NQO1. Mol. Nutr. Food Res. 2018, 62:1700969.
9. Structural basis, chemical driving forces and biological implications of flavones as Cu(II) ionophores. Free Radic. Biol. Med. 2017, 108:554-563.
10. Designing piperlongumine-directed anticancer agents by an electrophilicity-based prooxidant strategy: A mechanistic investigation. Free Radic. Biol. Med. 2016, 97:109-123.
1、代课情况：有机化学（口腔医学本科）、自由基化学（硕士研究生、生物有机（博士研究生）
