联系方式
职 称：
所在部门：有机化学第四研究所
研究方向：天然产物全合成、方法学及新型靶点抗生素、抗癌药物研发以及相关信号传导通路研究。
办 公 室 ：新化学楼306
联系电话：13639327968
电子邮件：wangxiaolei@lzu.edu.cn
兰州大学萃英特聘教授、博士生导师，甘肃省领军人才，国家青年人才计划入选者。2006年获得兰州大学化学基地班学士学位，2011年获得兰州大学有机化学博士学位，师从厍学功教授。2011-2015年，在美UT Southwestern Medical Center从事博士后研究，师从Chuo Chen教授，开展吡咯-氨基咪唑天然产物不对称全合成研究；2015-2017年，在The Scripps Research Institute从事研究助理工作，师从Chi-Huey Wong教授，开展以Transglycosylase为靶点的新型抗生素研发。迄今Science、J. Am. Chem. Soc.、JMC 等国际著名刊物上合作发表学术论文20余篇。
单萜吲哚生物碱strictamine、picrinine及aspidophylline的全合成及其生物活性研究， 青年基金，2018-2020 ，26.0；主持;
核苷类天然产物A201A/A201E合成及其构效关系研究，面上项目，2021-2024，63.0 主持.
有机化学
11) Wang, J.; Gao, J.; Guo, T.; Huo, X.; Zhang, W.; Liu, J.; Wang, X.* Bioinspired Total Synthesis of Complex Nucleoside Antibiotics A201A, A201D and A201E. Angew. Chem. Int. Ed., 2023, 62, e202213810.
10) Huang, W.; Fan, S.; Mao, J.; Luo, S.; Tang, S.; Liu, J.*; Wang, X.* Total Synthesis of Complex Peptidyl Nucleoside Antibiotics: Asymmetric De Novo Syntheses of Miharamycin B and Its Biosynthetic Precursor. Angew. Chem. Int. Ed., 2022, 61, e202204907.
9) Wu, M.; Jiang, Q.; Tian, Q.; Guo, T.; Cai, F.; Tang, S.; Liu, J. *; Wang, X.* Enzyme-like C–H Oxidation of Glucosides Promoted by Visible Light. CCS Chem.2022, 4, 3599–3608.
8) Xing, Z.; Fang, B.; Luo, S.; Xie, X.; Wang, X.* Generation of Fused Seven-Membered Polycyclic Systems via Ring Expansion and Application to the Total Synthesis of Sesquiterpenoids. Org. Lett. 2022, 24, 4034–4039.
7) Cao, H.; Guo, T.; Deng, X.; Huo, X.; Tang, S.; Liu, J.*; Wang, X.* Site-selective C–H alkylation of myo-inositol via organic photoredox catalysis. Chem. Commun., 2022, 58, 9934-9937.
6) Guo, T.; Wang, H.; Wang, C.; Tang, S.; Liu, J. *; Wang, X.* Nonenzymatic Asparagine Motif Synthesis by Photoredox-Catalyzed Carbamoylation of Dehydroalanine. J. Org. Chem.. 2022, 87, 6852–6859.
5.“Stereodivergent Synthesis of C-Glycosamino Acids via Pd/Cu Dual Catalysis”. Yan, X.; Feng, F.; Zhou, L.; Chen, L.; Tang, S.; Liu, J.; Cai, F.; Wang, X. *. Science China Chemistry. 2021, 64, 552-557.
4.“Discovery of A031 as Effective Proteolysis Targeting Chimera (PROTAC) Androgen Receptor (AR) Degrader for the Treatment of Prostate Cancer”. Chen, L.; Han, L.; Mao, S.; Xu, P.; Xu, X.; Zhao, R.; Wu, Z.; Zhong, K.; Yu, G.*.; Wang, X.*. European Journal of Medicinal Chemistry. 2021, 214, 113307-113319.
3.“Visible-light promoted dithioacetalization of aldehydes with thiols under aerobic and photocatalyst-free conditions”. Xing, Z.; Yang, M.; Sun, H.; Wang, Z.; Chen, P.; Liu, L.; Wang, X. * Xie, X.*.; She, X. Green Chem. 2018, 20, 5117.
2.“Asymmetric Syntheses of Sceptrin and Massadine and Evidence for Biosynthetic Enantiodivergence”. Ma, Z.; Wang, X.; Wang, X.; Gao, S.; Tan, X.; Ma, Y.; Lynch, V. M.; Chen, C. Science (Co-first auhor,Highlighted in C&EN News) 2014, 346, 219.
1. “The Development of Highly Potent Inhibitors for Porcupine”. Wang, X.; Moon, J.; Dodge, M.; Pan, X.; Zhang, L.; Hanson, J.; Tuladhar, R.; Ma, Z.; Shi, H.; Williams, N.; Amatruda, J.; Carroll, T.; Lum, L.; Chen, C. J. Med. Chem. 2013, 56, 2700–2704.
承担有机化学教学工作
