联系方式
陈建军,教授,硕士生导师,2004年毕业于忻州师范学院,获学士学位。2009年毕业于兰州大学获博士学位。2016-2017,在Scripps研究所进行访问学习。2009年至今在兰州大学功能有机分子化学国家重点实验室、化学化工学院从事教学和科研工作。主要从事新颖结构天然产物的高效发现、结构修饰及生物活性研究。担任Natural Products & Bioprospecting杂志的青年编委以及多个国际SCI杂志的审稿人。在J. Med. Chem.,Org. Lett.,J. Nat. Prod.,Eur. J. Med. Chem.等国际知名刊物上发表论文50余篇。先后主持国家自然科学基金4项,甘肃省自然科学基金1项,作为主要成员参与国家重点基础研究发展计划、甘肃省科技重大专项计划项目等。荣获甘肃省技术标兵,甘肃省青年教师成才奖等奖励。
1. 项目:
(1)国家自然科学基金面上项目 (81973193):对映-异海松烷二萜的定向发现及靶向Keap1/Nrf2/ARE信号通路的神经保护作用研究,主持
(2)国家自然科学基金面上项目 (22277045):枸杞内生真菌拮抗致病镰刀菌的先导物发现及作用机制研究,主持
(3)甘肃省科技重大专项计划项目 (21ZD4NA019):甘肃道地药材连作障碍的最小化微生物组修复治理技术研究及应用示范,参与
2.专利:
(1)一种植物来源的苦木素及其制备方法和应用 (ZL 2021 1 0029779.X)
(2)一种具有神经细胞保护活性的对映-异海松烷型二萜及其制备方法和
应用 (ZL 2022 1 0094535.4)
代表论文:
1. Euphohelides A−C, ent-Abietane-Type Norditerpene Lactones from Euphorbia helioscopia and Their Anti-Inflammatory Activities. Hong-Ying Yang, Weidong Yao, Pei-Zhi Huang, Hui Xu, Qian Ma, Xiaoming Chen, Jian-Jun Chen,*and Kun Gao*J. Nat. Prod., 2023, 86, 1003−1009.
2. Anti-inflammatory ent-cleistanthane-type diterpenoids from Phyllanthus rheophyticus. Hong-Ying Yang, Pei-Zhi Huang, Qian Ma, Yue Sun, Wei-Jiao Feng, Yi-Lin He, Jian-Jun Chen*, Kun Gao,* Phytochemistry, 2023, 212, 113723.
3. Jatrophane diterpenoids with cytotoxic activity from the whole plant of Euphorbia heliosocpia L. Yu-Bo Lu, Shangwen Luo, Yu-Xian Wang, Zi-Yun Feng, Kun Gao*, Jian-Jun Chen*. Phytochemistry , 2022, 203, 113420.
4. Quassinoids with Inhibitory Activities against Plant Fungal Pathogens from Picrasma javanica. Jian-Jun Chen, Wei Bai, Yu-Bo Lu, Zi-Yun Feng, Kun Gao,* and Jian-Min Yue*. J. Nat. Prod., 2021, 84, 2111−212
5. Herbicidins from Streptomyces sp. CB01388 Showing Anti-Cryptosporidium Activity. Jian-Jun Chen,
Mostafa E. Rateb, Melissa S. Love, Zhengren Xu, Dong Yang, Xiangcheng Zhu, Yong Huang, Li-Xing Zhao, Yi Jiang, Yanwen Duan, Case W. McNamara, and Ben Shen*. J. Nat. Prod. 2018, 81, 791−797
6. Comparative Studies of the Biosynthetic Gene Clusters for Anthraquinone-Fused Enediynes Shedding Light into the Tailoring Steps of Tiancimycin Biosynthesis. Xiaohui Yan#, Jian-Jun Chen#, Ajeeth Adhikari, Christiana N. Teijaro, Huiming Ge,
Ivana Crnovcic, Chin-Yuan Chang, Thibault Annaval, Dong Yang, Christoph Rader, and Ben Shen*,. Org. Lett. 2018, 20, 5918−5921(#co-first author)
7. Structurally Diverse Highly Oxygenated Triterpenoids from the Roots of Ailanthus altissima and Their Cytotoxicity. Wei Bai, Hong-Ying Yang, Xing-Zhi Jiao, Ke-Na Feng, Jian-Jun Chen,*and Kun Gao*. J. Nat. Prod. 2018, 81, 1777−1785
8. Rauvomines A and B, Two Monoterpenoid Indole Alkaloids from Rauvolfia vomitoria. Jun Zeng, Dong-Bo Zhang, Pan-Pan Zhou, Qi-Li Zhang, Lei Zhao, Jian-Jun Chen,*and Kun Gao*. Org. Lett. 2017, 19, 6192−6195
9. Genome Mining of Micromonospora yangpuensis DSM 45577 as a Producer of an Anthraquinone-Fused Enediyne. Xiaohui Yan#, Jian-Jun Chen#, Ajeeth Adhikari, Dong Yang, Ivana Crnovcic, Nan Wang, Chin-Yuan Chang, Christoph Rader, and Ben Shen*. Org. Lett. 2017, 19, 6192−6195(#co-first author)
1. 讲授课程:
有机化学
基础化学实验I
2. 教学奖励:
甘肃省高校青年教师教学竞赛二等奖
兰州大学青年教师教学竞赛一等奖
兰州大学隆基教学新秀奖、骨干奖
国家级一流本科课程(主要成员)