联系方式
董世辉教授 (Professor Shihui Dong)，博士生导师。男，1985年10月生。2006年本科毕业于武汉大学药学院药学专业。2006年至2011年，在中国科学院上海药物研究所（天然）药物化学专业攻读博士学位。2011年至2018年，在美国伊利诺伊大学芝加哥分校与厄巴纳-香槟分校从事博士后研究。2018年11月起在兰州大学化学化工学院工作。主持国家自然科学基金青年基金项目及兰州大学“萃英特聘教授”启动经费项目。目前的主要研究兴趣包括：新颖结构活性天然产物的基因组挖掘、生物合成途径及关键酶催化机理解析。
1、项目：2020-2022 国家自然科学基金青年基金项目
近5年代表性论文(Representative Publications)：
1. Recent Advances in the Discovery and Biosynthetic Study of Eukaryotic RiPP Natural Products. Shangwen Luo, Shi-Hui Dong*. Molecules 2019, 24, 1541-1555. (Invited Review)
2. Mechanistic Basis for Ribosomal Peptide Backbone Modifications. Shi-Hui Dong,1 Andi Liu,1 Nilkamal Mahanta, Douglas A. Mitchell,* and Satish K. Nair*. ACS Cent. Sci. 2019, 5， 842-851.
3. Biosynthesis of the RiPP Trojan Horse Antibiotic Microcin C is Directed by the N-Formyl Peptide Substrate. Shi-Hui Dong, Alexey Kulikovsky, Svetlana Dubiley, Konstantin Severinov*, and Satish K. Nair*. Chem. Sci. 2019, 10, 2391-2395.
4. Insights into AMS/PCAT transporters from biochemical and structural characterization of a double Glycine motif protease. Silvia C Bobeica,1 Shi-Hui Dong,1 Liujie Huo, Nuria Mazo, Martin I. McLaughlin, Gonzalo Jiménez-Osés, Satish K. Nair*, and Wilfred A van der Donk*. eLife 2019, 8, e42305.
5. Structural and Biochemical Studies of Non-native Agonists of the LasR Quorum-Sensing Receptor Reveal an L3 Loop "Out" Conformation for LasR. Matthew C. O’Reilly,1 Shi-Hui Dong,1 Francis M. Rossi, Kaleigh M. Karlen, Rohan S. Kumar, Satish K. Nair*, and Helen E. Blackwell*. Cell Chem. Biol. 2018, 20, 1128-1139.
6. Molecular basis for the substrate specificity of quorum signal synthases. Shi-Hui Dong, Nicole Frane, Quin H. Christensen, E. Peter Greenberg, Rajesh Nagarajan, and Satish K. Nair*. PNAS 2017, 114, 9092-9097.
7. The enterococcal cytolysin synthetase has an unanticipated lipid kinase fold. Shi-Hui Dong,1 Weixin Tang,1 Tiit Lukk, Satish K Nair, and Wilfred A van der Donk. eLife 2015, 4, e07607.
8. Applications of the class II lanthipeptide protease LicP for sequence-specific, traceless peptide bond cleavage. Weixin Tang,1 Shi-Hui Dong,1 Lindsay M. Repka, Chang He, Satish K Nair*, and Wilfred A van der Donk*. Chem. Sci. 2015, 6, 6270-6279.
1、代课情况：化学专业英语
