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张保新 首页>师资队伍 > 副教授/副研究员

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职　　称：副教授

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电子邮件：zhangbx@lzu.edu.cn

张保新，男，理学博士，副教授，硕士生导师。2010年毕业于兰州大学化学化工学院获学士学位,2015年6月毕业于兰州大学化学化工学院有机化学专业获博士学位,导师:房建国教授。2015年7月至今在兰州大学功能有机分子化学国家重点实验室从事教学和科研工作，主要研究领域为化学生物学及药物化学。

目前主持国家自然科学基金青年基金1项、甘肃省青年基金1项、中央高校基金1项，结题中央高校基金1项。

近期代表性工作:

· 1. Zhang, J.; Zhang, B.（共同一作）; Li, X.; Han, X.; Liu, R.; Fang, J. Small molecule inhibitors of mammalian thioredoxin reductase as potential anticancer agents: An update. Medicinal research reviews 2019, 39, 5-39.

· 2. Zhang, B.; Liu, Y.; Li, X.; Xu, J.; Fang, J. Small Molecules to Target the Selenoprotein Thioredoxin Reductase. Chemistry – An Asian Journal 2018, 13, 3593-3600.

· 3. Zhang, B.; Zhang, J.; Peng, S.; Liu, R.; Li, X.; Hou, Y.; Han, X.; Fang, J. Thioredoxin reductase inhibitors: a patent review. Expert opinion on therapeutic patents 2017, 27, 547-556.

· 4. Zhang, B.; Ge, C.; Yao, J.; Liu, Y.; Xie, H.; Fang, J. Selective Selenol Fluorescent Probes: Design, Synthesis, Structural Determinants, and Biological Applications. Journal of the American Chemical Society 2015, 137, 757-769.

· 5. Zhang, B.; Duan, D.; Ge, C.; Yao, J.; Liu, Y.; Li, X.; Fang, J. Synthesis of Xanthohumol Analogues and Discovery of Potent Thioredoxin Reductase Inhibitor as Potential Anticancer Agent. Journal of Medicinal Chemistry 2015, 58, 1795-1805.

· 6. Peng, S.; Zhang, B. （共同一作）; Meng, X.; Yao, J.; Fang, J. Synthesis of Piperlongumine Analogues and Discovery of Nuclear Factor Erythroid 2-Related Factor 2 (Nrf2) Activators as Potential Neuroprotective Agents. Journal of Medicinal Chemistry 2015, 58, 5242-5255.

· 7. Yao, J.; Zhang, B.; Ge, C.; Peng, S.; Fang, J. Xanthohumol, a Polyphenol Chalcone Present in Hops, Activating Nrf2 Enzymes To Confer Protection against Oxidative Damage in PC12 Cells. Journal of Agricultural and Food Chemistry 2015, 63, 1521-1531.

· 8. Peng, S.; Zhang, B.; Yao, J.; Duan, D.; Fang, J. Dual protection of hydroxytyrosol, an olive oil polyphenol, against oxidative damage in PC12 cells. Food & Function 2015, 6, 2091-2100.

· 9. Duan, D.; Zhang, B.; Yao, J.; Liu, Y.; Fang, J. Shikonin targets cytosolic thioredoxin reductase to induce ROS-mediated apoptosis in human promyelocytic leukemia HL-60 cells. Free Radical Biology and Medicine 2014, 70, 182-193.

· 10. Duan, D.; Zhang, B.; Yao, J.; Liu, Y.; Sun, J.; Ge, C.; Peng, S.; Fang, J. Gambogic acid induces apoptosis in hepatocellular carcinoma SMMC-7721 cells by targeting cytosolic thioredoxin reductase. Free Radical Biology and Medicine 2014, 69, 15-25.

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